Application
Immunohistochemistry staining of Caspase-12 in brain cortex tissue using Caspase-12 Antibody.| Product Name | Caspase-12 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Caspase 12 is involved in the apoptosis triggered by a stress on the endoplasmic reticulum. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase 12 activation results in cell death in the absence of the cytochrome c-dependent pathway. Recently caspase-12 has been suggested to affect signaling pathways linking some G-protein coupled receptors to alphaIIbbeta3 activation. Caspase-12 is ubiquitously expressed in mouse tissues. |
| Immunogen | Caspase-12 antibody was raised against amino acids 2 - 17 of Caspase-12 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Caspase-12 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CASP12 |
|---|---|
| Alternative Names | CASP12 Caspase 12 pseudogene 1 Caspase 12 CASP-12 Caspase 12 (gene/pseudogene) Inactive caspase-12 CASP12P1 |
Application
Immunohistochemistry staining of Caspase-12 in brain cortex tissue using Caspase-12 Antibody.| Application Notes | Caspase-12 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store Caspase-12 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.02% sodium azide. |
