This gene encodes one of two cannabinoid receptors. The
cannabinoids, principally delta-9-tetrahydrocannabinol and
synthetic analogs, are psychoactive ingredients of marijuana. The
cannabinoid receptors are members of the guanine-nucleotide-binding
protein (G-protein) coupled receptor family, which inhibit
adenylate cyclase activity in a dose-dependent, stereoselective and
pertussis toxin-sensitive manner. The two receptors have been found
to be involved in the cannabinoid-induced CNS effects (including
alterations in mood and cognition) experienced by users of
marijuana. Multiple transcript variants encoding two different
protein isoforms have been described for this gene. [provided by
RefSeq].1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This CB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-187 amino acids from the Central region of human CB1.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.