This gene encodes a component of the polycomb multiprotein
complex, which is required to maintain the transcriptionally
repressive state of many genes throughout development via chromatin
remodeling and modification of histones. Disruption of this gene in
mice results in male-to-female gonadal sex reversal. Mutations in
this gene are also associated with gonadal dysgenesis in humans.
Alternatively spliced transcript variants encoding different
isoforms have been noted for this gene.1) Biason-Lauber, A., et al. Am. J. Hum. Genet. 84(5):658-663(2009)
Immunogen
This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.
Western blot analysis in mouse testis tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.