Application
Immunohistochemistry staining of CBX4 in colon tissue using CBX4 Antibody.| Product Name | CBX4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CBX4, Chromobox homolog 4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, NBP16, NS5ATP1-binding protein 16, HPC2, Polycomb 2 homolog, PC2, Pc class 2 homolog |
| Product description | PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2. |
| Immunogen | CBX4 antibody was raised against amino acids 95 - 107 of CBX4 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| CBX4 antibody can be used in Western Blot, and immunohistochemistry starting at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CBX4 |
|---|---|
| Alternative Names | CBX4 Chromobox homolog 4 Chromobox protein homolog 4 E3 SUMO-protein ligase CBX4 NBP16 NS5ATP1-binding protein 16 HPC2 Polycomb 2 homolog PC2 Pc class 2 homolog |
Application
Immunohistochemistry staining of CBX4 in colon tissue using CBX4 Antibody.| Application Notes | CBX4 antibody can be used in Western Blot, and immunohistochemistry starting at 20 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store CBX4 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
