CD97, a CD55 Receptor, is a leukocyte antigen located on most activated leukocytes. CD97 is highly homologous to EMR2 with five EGF-like domains in the N-terminal extracellular domain, suggesting that it may be involved in cell signaling as well as in cell adhesion (Hamann et al., 1996). Two variants are produced by alternative splicing, where the shorter form lacks exons 5 and 6 and reduces the number of EGF-like domains from 5 to 3, compared to the full-length isoform. CD97 is associated with with the activated lesions of multiple sclerosis. CD97 expression is also implicated in the dedifferentiation of colon and thyroid tumors.
Immunogen
A portion of amino acids 220-270 of human Leukocyte Antigen CD97.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
IHCWB
CD97 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: