Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.1) Hunter, T. (1995) Cell 80, 225-236. Wells, N. J. et al. (1999) J. Cell. Sci. 112, 3361-3371. McGowan, C. H. and Russell, P. (1993) EMBO J. 12, 75-85.
Immunogen
CDC2 (Ab-19) antibody was raised against a peptide sequence around aa.17~21 (V-V-Y-K-G) derived from Human CDC2.