Application
Immunohistochemistry staining of CDC2 in thymus using CDC2 Antibody.Application
Immunohistochemistry staining of CDC2 in small intestine tissue using CDC2 Antibody.| Product Name | CDC2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK1, CDC28A, CDC2, CDKN1, Cyclin-dependent kinase 1, p34 protein kinase, p34CDC2, CDC2a, Cell cycle controller CDC2, Cell division protein kinase 1, PSTAIR |
| Product description | CDC2/CDK1, a CDC2/CDK -type protein kinase, regulates cell cycle transitions G1 to S and G2 to M. CDC2/CDK1 is maintained in an inactive state by phosphorylation by kinases MYT1 and WEE1. The active kinase, called the M-phase promoting factor, consists of a heterodimer with cyclin B, and final activation at G2/M results from CDC25 phosphatase-mediated dephosphorylation of CDC2/CDK1. The drug taxol has been shown to activate CDC2/CDK1 in MDA-MB-435 breast cancer cells, leading to cell cycle arrest at G2/M and to apoptosis. CDC2 has also been implicated in neurofibrillary degeneration in Alzheimer's disease and other neurodegenerative diseases. |
| Immunogen | CDC2 antibody was raised against amino acids surrounding Tyrosine 15 of CDC2 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| CDC2 antibody can be used in Western Blot, immunohistochemistry starting at 20 μg/mL, and flow cytometry.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CDK1 |
|---|---|
| Alternative Names | CDK1 CDC28A CDC2 CDKN1 Cyclin-dependent kinase 1 p34 protein kinase p34CDC2 CDC2a Cell cycle controller CDC2 Cell division protein kinase 1 PSTAIR |
| Tissue Specificity | pTyr15 |
Application
Immunohistochemistry staining of CDC2 in thymus using CDC2 Antibody.
Application
Immunohistochemistry staining of CDC2 in small intestine tissue using CDC2 Antibody.| Application Notes | CDC2 antibody can be used in Western Blot, immunohistochemistry starting at 20 μg/mL, and flow cytometry.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store CDC2 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.02% sodium azide, 50% glycerol. |
