Application
Antibody used in WB on Human 721_B at 1 ug/ml.Application
Antibody used in WB on Hum. Fetal Muscle at 1 ug/ml.Application
Antibody used in WB on Human 293T at 0.2-1 ug/ml.| Product Name | CHRFAM7A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHRFAM7A, CHRNA7, CHRNA7-DR1, D-10, MGC120482, MGC120483 |
| Product description | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.1) Martin, L.F., (2007) Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (5), 611-614. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRFAM7A. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| CHRFAM7A antibody can be used for detection of CHRFAM7A by ELISA at 1:62500. CHRFAM7A antibody can be used for detection of CHRFAM7A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CHRFAM7A |
|---|---|
| Alternative Names | CHRFAM7A CHRNA7 CHRNA7-DR1 D-10 MGC120482 MGC120483 |
| Molecular Weight(MW) | 35 kDa |
Application
Antibody used in WB on Human 721_B at 1 ug/ml.
Application
Antibody used in WB on Hum. Fetal Muscle at 1 ug/ml.
Application
Antibody used in WB on Human 293T at 0.2-1 ug/ml.| Positive Control | 1) 293T Cell Lysate |
|---|---|
| Application Notes | CHRFAM7A antibody can be used for detection of CHRFAM7A by ELISA at 1:62500. CHRFAM7A antibody can be used for detection of CHRFAM7A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store CHRFAM7A antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
