This gene encodes a subunit of the multi-component
CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and
degradation and is also thought to be involved in mRNA splicing,
transport and localization. The encoded protein interacts with
histone deacetylases and functions as a repressor of polymerase II
transcription. Alternatively spliced transcript variants have been
observed for this gene.1) Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
Immunogen
This CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the Central region of human CNOT2.
Western blot analysis in Jurkat cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.