Crystallins are separated into two classes: taxon-specific
and ubiquitous. The former class is also called
phylogenetically-restricted crystallins. The latter class
constitutes the major proteins of vertebrate eye lens and maintains
the transparency and refractive index of the lens. This gene
encodes a taxon-specific crystallin protein that binds NADPH and
has sequence similarity to bacterial ornithine cyclodeaminases. The
encoded protein does not perform a structural role in lens tissue,
and instead it binds thyroid hormone for possible regulatory or
developmental roles. Mutations in this gene have been associated
with autosomal dominant non-syndromic deafness. Multiple
alternatively spliced transcript variants have been found for this
gene.1) Martins-de-Souza, D., et al.Psychiatr Res (2010) In press :
Immunogen
This CRYM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the Central region of human CRYM.
Western blot analysis in mouse bladder tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.