Application
Immunohistochemistry staining of Cyclooxygenase-2 in liver tissue using Cyclooxygenase-2 Antibody.| Product Name | Cyclooxygenase-2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | COX2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged. Prostaglandin-endoperoxide synthase (fatty acid cyclooxygenase; PGH synthase; Cox-2) is a key enzyme in prostaglandin biosynthesis. The first rate-limiting step in the conversion of arachidonic acid to prostaglandins is catalyzed by Cox-1 and Cox-2. The cyclooxygenase activity of Cox-2 is inhibited by nonsteroidal antiinflammatory drugs such as aspirin and endomethacin. It is a mitogen-inducible gene (unlike Cox-1, which is a house-keeping gene), and this means it probably is a primary mediator of the inflammatory response. |
| Immunogen | Cyclooxygenase - 2 antibody was raised against a synthetic peptide corresponding to the C-Terminus of Cyclooxygenase - 2 (Rat). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIPWB |
| Cyclooxygenase-2 antibody can be used in immunohistochemistry starting at 2.4 μg/mL. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PTGS2 |
|---|---|
| Alternative Names | PTGS2 COX-2 Cyclooxygenase-2 COX2 Cyclooxygenase 2b HCox-2 GRIPGHS PGH synthase 2 PGHS-2 PHS II PHS-2 Prostaglandin H2 synthase 2 PGG/HS Prostaglandin G/H synthase 2 |
Application
Immunohistochemistry staining of Cyclooxygenase-2 in liver tissue using Cyclooxygenase-2 Antibody.| Application Notes | Cyclooxygenase-2 antibody can be used in immunohistochemistry starting at 2.4 μg/mL. |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store Cyclooxygenase-2 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, before the addition of glycerol to 40% |
