Application
Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10μg/mL.Application
Immunofluorescence of DcR2 in mouse kidney tissue withDcR2 antibody at 20 μg/ml.Application
Immunohistochemistry of DcR2 in mouse kidney node tissue with DcR2 antibody at 2.5 μg/ml.Application
Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 μg/mL.| Product Name | DcR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DcR2 Antibody: DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2 |
| Product description | DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.1) Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-3. |
| Immunogen | DcR2 antibody was raised against a 15 amino acid peptide near the center of human DcR2. The immunogen is located within amino acids 230 - 280 of DcR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICCIFIHC-PWB |
| DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and Immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TNFRSF10D |
|---|---|
| Alternative Names | DcR2 Antibody: DCR2 CD264 TRUNDD TRAILR4 TRAIL-R4 DCR2 UNQ251/PRO288 Tumor necrosis factor receptor superfamily member 10D Decoy receptor 2 DcR2 |
| Molecular Weight(MW) | Predicted: 36 kDa Observed: 36 kDa |
| Sequence Similarities | 2) Cat. No. 17-001 - HeLa Cell Slide |
Application
Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10μg/mL.
Application
Immunofluorescence of DcR2 in mouse kidney tissue withDcR2 antibody at 20 μg/ml.
Application
Immunohistochemistry of DcR2 in mouse kidney node tissue with DcR2 antibody at 2.5 μg/ml.
Application
Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1201 - HeLa Cell Lysate |
|---|---|
| Application Notes | DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and Immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | DcR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | DcR2 Antibody is supplied in PBS containing 0.02% sodium azide. |
