Probable ATP-dependent RNA helicase DDX20, Component of gems 3, DEAD box protein 20, DEAD box protein DP 103, Gemin-3, DDX20, DP103, GEMIN3
Product description
DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration
of RNA secondary structure such as translation initiation, nuclear
and mitochondrial splicing, and ribosome and spliceosome assembly.
Based on their distribution patterns, some members of this family
are believed to be involved in embryogenesis, spermatogenesis, and
cellular growth and division. This gene encodes a DEAD box protein,
which has an ATPase activity and is a component of the survival of
motor neurons (SMN) complex. This protein interacts directly with
SMN, the spinal muscular atrophy gene product, and may play a
catalytic role in the function of the SMN complex on RNPs.1) Todd, A.G., et al. J. Mol. Biol. 401(5):681-689(2010)
Immunogen
This DDX20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-741 amino acids from the C-terminal region of human DDX20.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.