Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.1) Wu C. -L., Zukerberg L. R., Ngwu C., Harlow E., Lees J. A. Mol. Cell. Biol. 15:2536-2546 (1995)
Immunogen
DP-1 antibody was raised against a peptide sequence around aa.13~17 (E-L-K-V-F) derived from Human DP-1.