Application
Antibody used in WB on Transfected 293T at 0.2-1 ug/ml.| Product Name | DYNLL1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DYNLL1, DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, MGC126137, MGC126138, PIN, hdlc1 |
| Product description | Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.1) Song, C., (2008) J. Biol. Chem. 283 (7), 4004-4013. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DYNLL1. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| DYNLL1 antibody can be used for detection of DYNLL1 by ELISA at 1:1562500. DYNLL1 antibody can be used for detection of DYNLL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DYNLL1 |
|---|---|
| Alternative Names | DYNLL1 DLC1 DLC8 DNCL1 DNCLC1 LC8 LC8a MGC126137 MGC126138 PIN hdlc1 |
| Molecular Weight(MW) | 10 kDa |
| Entrez Gene | 8655 |
|---|---|
| Protein Accession | NP_001032583 |
Application
Antibody used in WB on Transfected 293T at 0.2-1 ug/ml.| Positive Control | 1) Tranfected 293T Cell Lysate |
|---|---|
| Application Notes | DYNLL1 antibody can be used for detection of DYNLL1 by ELISA at 1:1562500. DYNLL1 antibody can be used for detection of DYNLL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store DYNLL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
