Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Tyr1092).| Product Name | EGFR (phospho Tyr1092) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERBB, HER1, mENA, ERBB1, PIG61, CREB2, CREBP1, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR |
| Product description | Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.1) Buerger C, et al. (2003) J Biol Chem; 278 (39): 37610-21. Wang XQ, (2003) J Biol Chem; 278 (49): 48770-8. Saito T, et al. (2004) Endocrinology; 145 (9): 4232-43. Pao W, et al. (2004) Proc Natl Acad Sci U S A; 101 (36): 13306-11. |
| Immunogen | EGFR (Phospho-Tyr1092) antibody was raised against a peptide sequence around phosphorylation site of tyrosine1092 (P-E-Y (p) -I-N) derived from Human EGFR. |
| Modification | p-Tyr1092 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | EGFR |
|---|---|
| Alternative Names | ERBB HER1 mENA ERBB1 PIG61 CREB2 CREBP1 Receptor protein-tyrosine kinase ErbB-1 kinase EGFR |
| Molecular Weight(MW) | 175 kDa |
| Tissue Specificity | This antibody detects endogenous level of EGFR only when phosphorylated at tyrosine 1092. |
| Entrez Gene | 1956 |
|---|---|
| Protein Accession | NP_005219.2 |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Tyr1092).| Application Notes | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
