ERBB-4 receptor tyrosine kinase is activated by neuregulins, nrg- 2, nrg-3, heparin-binding egf-like growth factor, betacellulin and ntak to regulate cell proliferation and differentiation. Several isoforms of the ERBB-4 receptor tyrosine kinase have been identified and differ functionally in their response to phorbol ester: they represent cleavable and noncleavable forms of the receptor. These isoforms are differentially expressed in tissues.
Immunogen
ERBB4 antibody was raised against a peptide located near the internal domain of ERBB4 (Human).
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
IHC
ERBB4 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, and immunoprecipitation: