This gene encodes an ETS family transcription factor. The
product of this gene contains two functional domains: a N-terminal
pointed (PNT) domain that is involved in protein-protein
interactions with itself and other proteins, and a C-terminal
DNA-binding domain. Gene knockout studies in mice suggest that it
is required for hematopoiesis and maintenance of the developing
vascular network. This gene is known to be involved in a large
number of chromosomal rearrangements associated with leukemia and
congenital fibrosarcoma.1) Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)
Immunogen
This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6.
Western blot analysis in mouse lung tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.