The ficolin family of proteins are characterized by the
presence of a leader peptide, a short N-terminal segment, followed
by a collagen-like region, and a C-terminal fibrinogen-like domain.
The collagen-like and the fibrinogen-like domains are also found
separately in other proteins such as complement protein C1q, C-type
lectins known as collectins, and tenascins. However, all these
proteins recognize different targets, and are functionally
distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in
the peripheral blood leukocytes, and has been postulated to
function as a plasma protein with elastin-binding activity.1) Honore, C., et al. J. Leukoc. Biol. 88(1):145-158(2010)
Immunogen
This FCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human FCN1.
Western blot analysis in K562 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.