The protein encoded by this gene is a member of the
fibroblast growth factor family. The fibroblast growth factors
possess broad mitogenic and cell survival activities, and are
involved in a variety of biological processes including embryonic
development, cell growth, morphogenesis, tissue repair, tumor
growth and invasion. This gene product is a secreted neurotrophic
factor but lacks a typical signal peptide. It is expressed in
normal brain, particularly the cerebellum, and may regulate central
nervous system development and function. Homodimerization of this
protein was shown to regulate its receptor binding activity and
concentration gradient in the extracellular matrix. Genetic
variations of this gene have been associated with Parkinson disease
susceptibility.1) de Mena, L., et al. Neurosci. Lett. 479(1):22-25(2010)
Immunogen
This FGF20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the C-terminal region of human FGF20.
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.