Application
Immunohistochemistry of GAS6 in mouse heart tissue with GAS6 antibody at 2.5 μg/mL.Application
Western blot analysis of GAS6 in mouse heart tissue lysate with GAS6 antibody at 1 μg/ml.| Product Name | GAS6 Antibody |
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| Antibody Type | Primary Antibodies |
| Product description | The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).1) Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93. |
| Immunogen | GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6. The immunogen is located within amino acids 60 - 110 of GAS6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA,IHC-P,WB |
| GAS6 antibody can be used for the detection of GAS6 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. | |
| Species Reactivity | Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GAS6 |
|---|---|
| Alternative Names | Growth arrest-specific 6 protein AXSF AXLLG |
| Molecular Weight(MW) | Predicted: 75 kDa Observed: 75 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Rabbit: (95%) |
| Tissue Specificity | GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform. |
Application
Immunohistochemistry of GAS6 in mouse heart tissue with GAS6 antibody at 2.5 μg/mL.
Application
Western blot analysis of GAS6 in mouse heart tissue lysate with GAS6 antibody at 1 μg/ml.| Application Notes | GAS6 antibody can be used for the detection of GAS6 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. |
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| Form | Liquid |
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| Storage Instructions | GAS6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | GAS6 Antibody is supplied in PBS containing 0.02% sodium azide. |
