The protein encoded by this gene is a member of the
somatotropin/prolactin family of hormones which play an important
role in growth control. The gene, along with four other related
genes, is located at the growth hormone locus on chromosome 17
where they are interspersed in the same transcriptional
orientation; an arrangement which is thought to have evolved by a
series of gene duplications. The five genes share a remarkably high
degree of sequence identity. Alternative splicing generates
additional isoforms of each of the five growth hormones, leading to
further diversity and potential for specialization. As in the case
of its pituitary counterpart, growth hormone 1, the predominant
isoform of this particular family member shows similar somatogenic
activity, with reduced lactogenic activity. Mutations in this gene
lead to placental growth hormone/lactogen deficiency. [provided by
RefSeq].1) McElholm, A.R., et al. Gastroenterology 139(1):204-212(2010)
Immunogen
This GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human GH2.
Western blot analysis in human placenta tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.