The GLP2 receptor (GLP2R) is a G protein-coupled receptor
superfamily member closely related to the glucagon receptor ans
GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid
proglucagon-derived peptide produced by intestinal enteroendocrine
cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it
is derived from the proglucagon peptide encoded by the GCG gene.
GLP2 stimulates intestinal growth and upregulates villus height in
the small intestine, concomitant with increased crypt cell
proliferation and decreased enterocyte apoptosis. Moreover, GLP2
prevents intestinal hypoplasia resulting from total parenteral
nutrition. GLP2R, a G protein-coupled receptor superfamily member
is expressed in the gut and closely related to the glucagon
receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by
RefSeq].1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This GLP2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-248 amino acids from the Central region of human GLP2R.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.