Application
Immunohistochemistry staining of GPR182 in adrenal tissue using GPR182 Antibody.| Product Name | GPR182 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | G Protein-Coupled Receptor L1/G10D (GPR182) has been suggested to be an Adrenomedullin Receptor. Originally cloned from rats and later from humans, L1/G10D does not to bind adrenomedullin or display functional cAMP response to adrenomedullin (reviewed in Poyner et al. 2002). The initial experimental results, which demonstrated high-affinity binding and increased levels of cAMP in COS cells that were transfected with L1/G10D and treated with adrenomedullin, could not be reproduced by other laboratories (Kapas et al. 1995). It is now known that the functional adrenomedullin receptor is a heterodimeric complex composed of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) (McLatchie et al. 1998). L1/G10D therefore should be considered an Orphan A receptor. |
| Immunogen | GPR182 antibody was raised against a peptide located in the 2nd extracellular domain of GPR182 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| GPR182 antibody can be used in immunohistochemistry starting at 11 μg/mL. | |
| Species Reactivity | GibbonGorillaHumanMonkey |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GPR182 |
|---|---|
| Alternative Names | GPR182 7TMR Adrenomedullin L1 receptor AM-R AMR ADMR Adrenomedullin receptor G protein-coupled receptor 182 HrhAMR G-protein coupled receptor 182 Gamrh HAMR RAMR G10D |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of GPR182 in adrenal tissue using GPR182 Antibody.| Application Notes | GPR182 antibody can be used in immunohistochemistry starting at 11 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | GPR182 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
