Grik2 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.1) Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
Immunogen
Grik2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Grik2. The immunogen is located within the last 50 amino acids of Grik2.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAWB
Grik2 antibody can be used for detection of Grik2 by Western blot at 0.5 - 1 μg/mL.:
Western blot analysis of Grik2 in human brain tissue lysate with Grik2 antibody at (A) 0.5 and (B) 1 μg/mL.
Positive Control
1) Cat. No. 1303 - Human Brain Tissue Lysate
Application Notes
Grik2 antibody can be used for detection of Grik2 by Western blot at 0.5 - 1 μg/mL.:
Additional Information
Form
Liquid
Storage Instructions
Grik2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer
Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.