Application
Immunohistochemistry staining of GRM6 in eye, ganglion cells using GRM6 Antibody.| Product Name | GRM6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRM6, CSNB1B, GPRC1F, MGlu6, MGLUR6 |
| Product description | Metabotropic Glutamate Receptor GRM6 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and Group III receptors are linked to the inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities. |
| Immunogen | GRM6 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM6 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| GRM6 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
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| Species Reactivity | ChimpanzeeGibbonGorillaHumanMonkey |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GRM6 |
|---|---|
| Alternative Names | GRM6 CSNB1B GPRC1F MGlu6 MGLUR6 |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of GRM6 in eye, ganglion cells using GRM6 Antibody.| Application Notes | GRM6 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | GRM6 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
