Application
Immunohistochemistry staining of Histone Deacetylase 4 in lung, respiratory epithelium tissue using Histone Deacetylase 4 Antibody.| Product Name | Histone Deacetylase 4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. |
| Immunogen | Histone Deacetylase 4 antibody was raised against amino acids 194 - 209 of Histone Deacetylase 4 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIPWB |
| Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 μg/mL. | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | HDAC4 |
|---|---|
| Alternative Names | HDAC4 BDMR AHO3 Histone deacetylase A HD4 HA6116 HDAC-A HDACA Histone deacetylase 4 HDAC-4 KIAA0288 |
| Tissue Specificity | A 140 kD band is observed. |
Application
Immunohistochemistry staining of Histone Deacetylase 4 in lung, respiratory epithelium tissue using Histone Deacetylase 4 Antibody.| Application Notes | Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 μg/mL. |
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| Form | Liquid |
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| Storage Instructions | Histone Deacetylase 4 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS containing 0.05% BSA and 0.05% sodium azide |
