Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E, HOXD10, HOX4D, HOX4E
Product description
This gene is a member of the Abd-B homeobox family and
encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox D genes located on chromosome 2.
The encoded nuclear protein functions as a sequence-specific
transcription factor that is expressed in the developing limb buds
and is involved in differentiation and limb development. Mutations
in this gene have been associated with Wilm's tumor and congenital
vertical talus (also known as 'rocker-bottom foot' deformity or
congenital convex pes valgus) and/or a foot deformity resembling
that seen in Charcot-Marie-Tooth disease.1) Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Immunogen
This HOXD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the C-terminal region of human HOXD10.
Western blot analysis in zebra fish brain tissue lysates (35ug/lane).
Application
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.