Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HP1alpha (Phospho-Ser92) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | HP1alpha (phospho Ser92) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HP1A, HP1 alpha, antigen p25 |
| Product description | Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.1) Saunders W.S., J. Cell Sci. 104:573-582(1993). |
| Immunogen | HP1alpha (phospho Ser92) antibody was raised against a peptide sequence around phosphorylation site of Serine 92 (R-S-S (p)-N-F) derived from Human HP1alpha . |
| Modification | p-Ser92 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CBX5 |
|---|---|
| Alternative Names | HP1A HP1 alpha antigen p25 |
| Molecular Weight(MW) | 22 kDa |
| Tissue Specificity | The antibody detects endogenous levels of HP1alpha only when phosphorylated at serine 92. |
| Entrez Gene | 23468 |
|---|---|
| Protein Accession | NP_001120793.1 |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HP1alpha (Phospho-Ser92) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
