Application
Immunohistochemistry staining of HSP90B2P in kidney tissue using HSP90B2P Antibody.| Product Name | HSP90B2P Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HSP90AA1, EL52, HSP86, Hsp89, HSP89A, HSPC1, Heat shock 86 kDa, Hsp90, HSP90A, HSP90N, HSPCA, HSPCAL4, HSPN, LAP2, HSP 86, HSPCAL1 |
| Product description | Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3. |
| Immunogen | HSP90B2P antibody was raised against amino acids 289-300 of HSP90B2P (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| HSP90B2P antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, immunoprecipitation, and flow cytometry.: |
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| Species Reactivity | ChickenDrosophilaHumanMonkeyMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HSP90AA1 |
|---|---|
| Alternative Names | HSP90AA1 EL52 HSP86 Hsp89 HSP89A HSPC1 Heat shock 86 kDa Hsp90 HSP90A HSP90N HSPCA HSPCAL4 HSPN LAP2 HSP 86 HSPCAL1 |
Application
Immunohistochemistry staining of HSP90B2P in kidney tissue using HSP90B2P Antibody.| Application Notes | HSP90B2P antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, immunoprecipitation, and flow cytometry.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store HSP90B2P antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
