CC3 (HTATIP2) is a member of the short-chain dehydrogenases/reductases (SDR) family. It is a novel serine/threonine kinase that phosphorylates the C-terminal domain (CTD) of the largest RNA polymerase II subunit and induces the expression of apoptosis related genes Bad and Siva, as well as metastasis suppressor NM23-H2. It also interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates ERalpha-mediated c-myc transcription.1) Jiang, C., et al., (2004) J.Biol.Chem.279(26), 27781-27789.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HTATIP2.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHCWB
HTATIP2 antibody can be used for detection of HTATIP2 by ELISA at 1:1562500. HTATIP2 antibody can be used for detection of HTATIP2 by western blot at 0.5-1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Antibody used in WB on Human Jurkat 0.5-1.0 ug/ml.
Application
Antibody used in IHC on Human Liver.
Application
Antibody used in IHC on Human Lung.
Positive Control
1) Cat. No. 1205 - Jurkat Cell Lysate
Application Notes
HTATIP2 antibody can be used for detection of HTATIP2 by ELISA at 1:1562500. HTATIP2 antibody can be used for detection of HTATIP2 by western blot at 0.5-1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store HTATIP2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 200 μL of distilled water. Final antibody concentration is 1 mg/mL.