| Product Name | Huntington Protein Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HD, IT15, HD |
| Product description | Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington’s disease protein is ~350 kDa in size and is localized in the brain.1) Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412(2):191-209 |
| Immunogen | A synthetic peptide corresponding to the N-terminus. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ELISA, Western (immuno) blotting, Immunostaining (in testing): |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HTT |
|---|---|
| Alternative Names | HD IT15 HD |
| Application Notes | ELISA, Western (immuno) blotting, Immunostaining (in testing): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
