Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody (left) or the same antibody preincubated with blocking peptide (right).Application
Western blot analysis of extracts from COS-7 cells treated with UV using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | IGF2R (phospho Ser2409) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CI-MPR, CI-MPR, MPR300, MPRI |
| Product description | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.1) Morgan D.O., Nature 329:301-307(1987). |
| Immunogen | IGF2R (phospho Ser2409) antibody was raised against a peptide sequence around phosphorylation site of Serine 2409 (Q-D-S (p)-E-D) derived from Human IGF2R. |
| Modification | p-Ser2409 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IGF2R |
|---|---|
| Alternative Names | CI-MPR CI-MPR MPR300 MPRI |
| Molecular Weight(MW) | 300 kDa |
| Tissue Specificity | The antibody detects endogenous levels of IGF2R only when phosphorylated at serine 2409. |
| Entrez Gene | 3482 |
|---|---|
| Protein Accession | NP_000867.2 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody (left) or the same antibody preincubated with blocking peptide (right).
Application
Western blot analysis of extracts from COS-7 cells treated with UV using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
