Application
Western blot analysis of 1 ng of recombinant human IL-17 with IL-17 antibody at 1 μg/ml.| Product Name | IL-17 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8 |
| Product description | IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.1) Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr. Opin. Rheumatol.2000; 12:181-5. |
| Immunogen | IL-17 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-17A. The immunogen is located within amino acids 50 - 100 of IL-17. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| IL-17 antibody can be used for the detection of IL-17 by Western blot at 1 - 2 μg/ml: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IL17A |
|---|---|
| Alternative Names | IL-17 Antibody: IL17 CTLA8 IL-17 IL-17A IL17 Interleukin-17A Cytotoxic T-lymphocyte-associated antigen 8 |
| Sequence Similarities | 2) Cat. No. 1288 – A-20 Cell Lysate |
Application
Western blot analysis of 1 ng of recombinant human IL-17 with IL-17 antibody at 1 μg/ml.| Positive Control | 1) Cat. No. 1314 - Human Thymus Tissue Lysate |
|---|---|
| Application Notes | IL-17 antibody can be used for the detection of IL-17 by Western blot at 1 - 2 μg/ml: |
| Form | Liquid |
|---|---|
| Storage Instructions | IL-17 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | IL-17 Antibody is supplied in PBS containing 0.02% sodium azide. |
