Application
Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 μg/ml.Application
Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 μg/ml.Application
Immunofluorescence of IL-17RA in human spleen tissue with IL-17RA antibody at 20 μg/ml.Application
Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 μg/mL.| Product Name | IL-17RA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL-17RA Antibody: CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R, Interleukin-17 receptor A, IL-17 receptor A |
| Product description | IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).1) Yao Z, Painter SL, Fanslow WC, et al. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 1995; 155: 5483-6. |
| Immunogen | IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA. The immunogen is located within amino acids 150 - 200 of IL-17RA. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IL17RA |
|---|---|
| Alternative Names | IL-17RA Antibody: CD217 IL17R CANDF5 CDw217 IL-17RA hIL-17R Interleukin-17 receptor A IL-17 receptor A |
| Molecular Weight(MW) | Predicted: 95 kDa Observed: 135 kDa |
| Sequence Similarities | 2) Cat. No. 10-901 - Human Spleen Tissue Slide |
| Tissue Specificity | IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits. |
Application
Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 μg/ml.
Application
Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 μg/ml.
Application
Immunofluorescence of IL-17RA in human spleen tissue with IL-17RA antibody at 20 μg/ml.
Application
Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1288 - A20 Cell Lysate |
|---|---|
| Application Notes | IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | IL-17RA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide. |
