This gene encodes a member of the IQGAP family. The
protein contains four IQ domains, one calponin homology domain, one
Ras-GAP domain and one WW domain. It interacts with components of
the cytoskeleton, with cell adhesion molecules, and with several
signaling molecules to regulate cell morphology and motility.
Expression of the protein is upregulated by gene amplification in
two gastric cancer cell lines.1) Hayashi, H., et al. Int. J. Cancer 126(11):2563-2574(2010)
Immunogen
This IQGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-285 amino acids from the N-terminal region of human IQGAP1.
Western blot analysis in T47D cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.