Application
Immunohistochemistry staining of KIT Oncogene in spleen, lymphocytes within periarteriolar lymphoid sheaths tissue using KIT Oncogene Antibody.| Product Name | KIT Oncogene Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Somatic gain-of-function mutations in the extracellular domain, kinase domains 1 and 2 are found in gastrointestinal stromal tumors (GISTs). Mutations in c-KIT gene are also associated with mast cell disease, acute myelogenous lukemia, and piebaldism. Tyrosine kinase inhibitor STI571 has been shown to inhibit GIST cells that express mutated c-KIT. |
| Immunogen | KIT Oncogene antibody was raised against a peptide located in the cytoplasmic domain of KIT Oncogene (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| KIT Oncogene antibody can be used in ELISA starting at 1:10000, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200 - 1:400. | |
| Species Reactivity | BatBovineDogGibbonGoatGorillaHorseHumanMonkeyPigRabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KIT |
|---|---|
| Alternative Names | KIT C-Kit CD117 PBT Piebald trait Piebald trait protein Proto-oncogene c-Kit SCFR Soluble KIT variant 1 Tyrosine-protein kinase Kit p145 c-kit CD117 antigen |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of KIT Oncogene in spleen, lymphocytes within periarteriolar lymphoid sheaths tissue using KIT Oncogene Antibody.| Application Notes | KIT Oncogene antibody can be used in ELISA starting at 1:10000, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200 - 1:400. |
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| Form | Liquid |
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| Storage Instructions | KIT Oncogene antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
