Application
Western blot analysis of LGP2 in rat kidney tissue lysate with LGP2 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | LGP2 Antibody |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | LGP2 Antibody: LGP2, RLR-3, D11LGP2, D11lgp2e, D11LGP2E, LGP2, Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2 |
| Product description | LGP2 Antibody: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling.1) Akira S, Uematsu S, and Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801. |
| Immunogen | LGP2 antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human LGP2. The immunogen is located within amino acids 570 - 620 of LGP2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| LGP2 antibody can be used for detection of LGP2 by Western blot at 1 - 2 μg/mL.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DHX58 |
|---|---|
| Alternative Names | LGP2 Antibody: LGP2 RLR-3 D11LGP2 D11lgp2e D11LGP2E LGP2 Probable ATP-dependent RNA helicase DHX58 Probable ATP-dependent helicase LGP2 |
| Molecular Weight(MW) | Predicted: 70 kDa Observed: 75 kDa |
| Tissue Specificity | At least four isoforms of LGP2 are known to exist. |
Application
Western blot analysis of LGP2 in rat kidney tissue lysate with LGP2 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1465 - Rat Kidney Tissue Lysate |
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| Application Notes | LGP2 antibody can be used for detection of LGP2 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
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| Storage Instructions | LGP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LGP2 Antibody is supplied in PBS containing 0.02% sodium azide. |
