Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1,
Product description
LINGO1 is a functional component of the Nogo receptor signaling complex(RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.1) Inoue,H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)
Immunogen
This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human LINGO1.
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Leucine-rich repeat and immunoglobulin domain-containing protein 1 Leucine-rich repeat neuronal protein 1 Leucine-rich repeat neuronal protein 6A LINGO1
Molecular Weight(MW)
70 kDa
Sequence Similarities
Predicted species reactivity based on immunogen sequence: Monkey
Western blot analysis of LINGO1 Antibody in mouse cerebellum tissue lysates (35ug/lane)
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.