Application
Immunohistochemistry staining of LTK in colon, lamina propria plasma cells using LTK Antibody.| Product Name | LTK Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LTK, Leukocyte tyrosine kinase, Protein tyrosine kinase 1, TYK1 |
| Product description | Leukocyte tyrosine kinase (LTK) is a receptor-type protein tyrosine kinase, belonging to the insulin receptor superfamily, and is mainly expressed in B lymphocyte precursors and neuronal tissues. LTK utilizes insulin receptor substrate-1 (IRS-1) and Shc as major two substrates and possesses two NPXY motifs for them separately, tyrosine 485 of one NPXY motif at the juxtamembrane domain for IRS-1 and tyrosine 862 of another NPXY motif at the carboxyl-terminal domain for Shc. It has also been shown that p85 subunit of PI3 kinase directly binds to tyrosine 753 of LTK, which is located within a YXXM motif. Tyrosine 485 and 753 are responsible for IRS-1 and PI3K mediated survival effects of LTK, respectively. |
| Immunogen | LTK antibody was raised against amino acids 800 - 864 of LTK (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| LTK antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | LTK |
|---|---|
| Alternative Names | LTK Leukocyte tyrosine kinase Protein tyrosine kinase 1 TYK1 |
| Tissue Specificity | The amino acid sequence used as immunogen has 100% identity in human isoforms 1 and 2, and 81% homologous in mouse isoforms A, B, C, and D, and rat. LTK is an 864 amino acid protein with an approximate molecular weight of 94 kD. |
Application
Immunohistochemistry staining of LTK in colon, lamina propria plasma cells using LTK Antibody.| Application Notes | LTK antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | LTK antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.2% gelatin, 0.05% sodium azide. |
