The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.1) DeGiorgis J. A., Jaffe H., Moreira J. E., Carlotti C. G. Jr., Leite J. P., Pant H. C., Dosemeci A. J. Proteome Res. 4:306-315 (2005) Olsen J. V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648 (2006) Matsuoka S., Ballif B. A., Smogorzewska A., McDonald E. R. III, Hurov K. E., Luo J., Bakalarski C. E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S. P., Elledge S. J. Science 316:1160-1166 (2007)
Immunogen
MAP2 antibody was raised against a peptide sequence around aa.1819~1823 (T-A-A-L-A) derived from Human MAP2.