JNK2, a MAPK type protein kinase, regulates cell apoptosis, differentiation and growth in response to growth factors, inflammatory cytokines and cellular stress. JNK2 is phosphorylated by by MKK4/MAP2K4 and MKK7/MAP2K7. Activated JNK2 translocates to the nucleus where it phosphorylates transcription factors, including c-Jun, ATF2, ELK1, Jun-D and NFAT4. At least four distinct isoforms, resulting from alternatively spliced transcript variants, have been reported - three different isoforms comprised of 382 amino acids and one comprised of 424 amino acids.
Immunogen
A synthetic peptide corresponding to amino acids 373-389 (KDQPSDAAVSSNATPSQ) of human JNK2, GenBank no. gi|21237736|ref|NP_002743.3|. This amino sequence is 100% homologous in cow and dog, and 94% in mouse and rat. Percent identity by BLAST analysis: ...