The proto-oncogene MET product is the hepatocyte growth
factor receptor and encodes tyrosine-kinase activity. The primary
single chain precursor protein is post-translationally cleaved to
produce the alpha and beta subunits, which are disulfide linked to
form the mature receptor. Various mutations in the MET gene are
associated with papillary renal carcinoma. Two transcript variants
encoding different isoforms have been found for this gene.1) Song, J., et al. Arch. Pathol. Lab. Med. 134(11):1702-1705(2010)
Immunogen
This ZNF593 antibody is generated from rabbits immunized with a His fusion protein from human MET.
Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.