MKNK2 may play a role in the response to environmental stress and cytokines. This protein appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.1) Scheper, G.C., et al., Mol. Cell. Biol. 23(16):5692-5705 (2003). Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001). Scheper, G.C., et al., Mol. Cell. Biol. 21(3):743-754 (2001). Slentz-Kesler, K., et al., Genomics 69(1):63-71 (2000). Haribabu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 90(20):9398-9402 (1993).
Immunogen
This MNK2 (MKNK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-432 amino acids from the C-terminal region of human MNK2 (MKNK2).
Western blot analysis of MNK2 (MKNK2) antibody in 293 cell line lysates (35ug/lane)
Application
Western Blot at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.