Application
Immunohistochemistry staining of MRE11A in brain cortex tissue using MRE11A Antibody.| Product Name | MRE11A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MRE11A, AT-like disease, Endo/exonuclease Mre11, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11B, ATLD |
| Product description | Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1), which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Mre11 is a nuclear protein that is widely expressed and localizes to discrete nuclear foci after treatment with genotoxic agents (including irradiation). Alternative splice isoforms are recorded for this protein. |
| Immunogen | MRE11A antibody was raised against amino acids 68 - 706 of MRE11A (Mouse). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| MRE11A antibody can be used in ELISA starting at 1:5000 - 1:25000, Western Blot starting at 1:500 - 1:3000, immunohistochemistry starting at 2.5 μg/mL, and immunofluorescence.: |
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| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MRE11A |
|---|---|
| Alternative Names | MRE11A AT-like disease Endo/exonuclease Mre11 HNGS1 MRE11 MRE11 homolog 1 MRE11 homolog A MRE11B ATLD |
Application
Immunohistochemistry staining of MRE11A in brain cortex tissue using MRE11A Antibody.| Application Notes | MRE11A antibody can be used in ELISA starting at 1:5000 - 1:25000, Western Blot starting at 1:500 - 1:3000, immunohistochemistry starting at 2.5 μg/mL, and immunofluorescence.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store MRE11A antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
