This gene encodes a member of the mutS family of proteins
that are involved in DNA mismatch repair and meiotic recombination.
This protein is similar to a Saccharomyces cerevisiae protein that
participates in segregation fidelity and crossing-over events
during meiosis. This protein plays a role in promoting ionizing
radiation-induced apoptosis. This protein forms heterooligomers
with another member of this family, mutS homolog 4. Polymorphisms
in this gene have been linked to various human diseases, including
IgA deficiency, common variable immunodeficiency, and premature
ovarian failure. Alternative splicing results multiple transcript
variants.1) Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Immunogen
This MSH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 525-552 amino acids from the Central region of human MSH5.
Western blot analysis in HL-60 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.