Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | MYT1 (phospho Ser83) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.1) Booher R.N., J. Biol. Chem. 272:22300-22306(1997). |
| Immunogen | MYT1 (phospho Ser83) antibody was raised against a peptide sequence around phosphorylation site of Serine 83 (R-V-S (p)-F-R) derived from Human MYT1. |
| Modification | p-Ser83 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PKMYT1 |
|---|---|
| Alternative Names | PMYT1 PKMYT1 MYT1 kinase |
| Molecular Weight(MW) | 54 kDa |
| Tissue Specificity | The antibody detects endogenous levels of MYT1 only when phosphorylated at serine 83. |
| Entrez Gene | 9088 |
|---|---|
| Protein Accession | XP_006721039.1 |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody (left) or the same antibody preincubated with blocking peptide (right).| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
