Application
Immunofluorescence of NALP6 in human brain tissue with NALP6 antibody at 20 μg/mL.Application
Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | NALP6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | NALP6 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104. |
| Immunogen | NALP6 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NALP6. The immunogen is located within amino acids 150 - 200 of NALP6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFWB |
| NALP6 antibody can be used for detection of NALP6 by Western blot at 1 μg/mL. Antibody can also be used for immunoflourenscence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NLRP6 |
|---|---|
| Alternative Names | NALP6 Antibody: AVR NAVR PAN3 NALP6 PYPAF5 CLR11.4 NAVR/AVR NACHT LRR and PYD domains-containing protein 6 PYRIN-containing APAF1-like protein 5 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunofluorescence of NALP6 in human brain tissue with NALP6 antibody at 20 μg/mL.
Application
Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1301 - Human Heart Tissue Lysate |
|---|---|
| Application Notes | NALP6 antibody can be used for detection of NALP6 by Western blot at 1 μg/mL. Antibody can also be used for immunoflourenscence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | NALP6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | NALP6 Antibody is supplied in PBS containing 0.02% sodium azide. |
