Application
Immunohistochemistry staining of NOTCH2 in liver tissue using NOTCH2 Antibody.| Product Name | NOTCH2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NOTCH2, AGS2, HN2, Notch (Drosophila) homolog 2, Notch homolog 2 (Drosophila), Notch 2, Notch homolog 2, HJCYS |
| Product description | Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane. |
| Immunogen | NOTCH2 antibody was raised against amino acids from the C-Terminus of NOTCH2 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| NOTCH2 antibody can be used in immunohistochemistry starting at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Sterile Filtration |
| Gene Symbol | NOTCH2 |
|---|---|
| Alternative Names | NOTCH2 AGS2 HN2 Notch (Drosophila) homolog 2 Notch homolog 2 (Drosophila) Notch 2 Notch homolog 2 HJCYS |
Application
Immunohistochemistry staining of NOTCH2 in liver tissue using NOTCH2 Antibody.| Application Notes | NOTCH2 antibody can be used in immunohistochemistry starting at 20 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store NOTCH2 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
