Application
Antibody is used in Western blot to detect OAS3 in A375 lysate.| Product Name | OAS3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3 |
| Product description | OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.1) Ito, M., et al., Cancer Res. 61(5):2038-2046 (2001). Rebouillat, D., et al., Genomics 70(2):232-240 (2000). Rebouillat, D., et al., J. Biol. Chem. 274(3):1557-1565 (1999). |
| Immunogen | This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | OAS3 |
|---|---|
| Alternative Names | 2'-5'-oligoadenylate synthase 3 (2-5')oligo(A) synthase 3 2-5A synthase 3 p100 OAS p100OAS OAS3 |
| Molecular Weight(MW) | 121 kDa |
Application
Antibody is used in Western blot to detect OAS3 in A375 lysate.| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
